INA – Instituto de Nanociencia de Aragón

Nanobiomedicine

  Nanobiomedicine

  • Bacterias - SEM

Nanobiomedicine uses nanotechnology to improve the ability of medicine to study, diagnose and treat the most common illnesses of the population. New possibilities rise in order to establish new approaches targeted to customized therapies, drug delivery drugs with reduced toxicity and side effects in patient. New devices are developed, such as specific sensors. Also, medical imaging techniques (MRI) are improved thanks to Nanotechnology.

The Nanobiomedicine area covers different aspects of the diagnosis, therapy and toxicity, which involve the use of nanostructured materials.

The Institute of Nanoscience of Aragon syntethizes, characterizes and functionalizes nanomaterials which are afterwards used in biomedical applications: Nanotherapy, Nanodiagnosis and Toxicity determination.

- Nanotherapy:

Drug delivery systems based on:

• Cell and biomolecular recognition.
• Magnetic attraction addressing.
• Porous nanostructured materials for continuous drug delivery.

Inmunotherapy:

• Dendritic cell culture for cancer immunotherapy.

Hyperthermia:

• In-vitro and in-vivo cell ablation and drug release mediated by nanoparticles: Magnetic and Optical Hyperthermia.

- Nanotoxicity:

Biocompatiblity surveys:
• Cell response against new materials.
• Proteins – nanoparticles interactions.
• Nanoparticles sterilization protocols.

Citotoxicity:
• Citotoxicity in different lines of cells.

Biodistribution:
• Aggregation and stability in biological fluids.
• Nanosafety: Environmental dispersion and entrapment of nanoparticles

- Nanomaterials for biomedical applications:

Synthesis of Nanostructured Materials:

• Magnetic nanoparticles.
• Core-shell nanoparticles.
• Nano and Microcapsules.
• Metallic nanoparticles with bactericide activity.
• Inorganic nanoparticles.
• Nanoparticles in ferritine.
• Dendrimers.
• Porous nano and microspheres.
• Porous interphases and membranes.
• Carbon nanotubes and nanofibres.

Characterization:

• 2D and 3D biological samples.
• Physico-chemical properties.
• Magnetic properties.
• Surface properties of biological samples.

Biofunctionalization of nanostructures:

• Direct nanoestructuration of biomaterials on different surfaces.
• Combination of nanostructures with biomolecules.

- Nanodiagnosis:

Design, fabrication and characterization of biosensor:

• Based on magnetic detection: Magnetoresistives and inductives.
• Chemical Sensors for molecular recognition by mean of zeolites nanoporous membranes.
• Optical Biosensors based on proteins.
• Biosensors functionalized with proteins, carbohydrates and peptides for biological recognition.

Biomedical identification systems:

• New diagnosis systems and identification of new therapeutical targets using genomic and proteomic techniques.
• Identification of new tumour markers.

Contrast agents for medical imaging:

• New Contrast Agents for medical imaging based on magnetic nanoparticles.